Hippocampal long-term depression mediates acute stress-induced spatial memory retrieval impairment
- 3 July 2007
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences of the United States of America
- Vol. 104 (27), 11471-11476
- https://doi.org/10.1073/pnas.0702308104
Abstract
Acute stress impairs memory retrieval and facilitates the induction of long-term depression (LTD) in the hippocampal CA1 region of the adult rodent brain. However, whether such alterations in synaptic plasticity cause the behavioral effects of stress is not known. Here, we report that two selective inhibitors of the induction or expression of stress-enabled, N-methyl-d-aspartate receptor-dependent hippocampal LTD also block spatial memory retrieval impairments caused by acute stress. Additionally, we demonstrate that facilitating the induction of hippocampal LTD in vivo by blockade of glutamate transport mimics the behavioral effects of acute stress by impairing spatial memory retrieval. Thus, the present study demonstrates that hippocampal LTD is both necessary and sufficient to cause acute stress-induced impairment of spatial memory retrieval and provides a new perspective from which to consider the nature of cognitive deficits in disorders whose symptoms are aggravated by stress.This publication has 49 references indexed in Scilit:
- Tyrosine phosphorylation of the GluR2 subunit is required for long‐term depression of synaptic efficacy in young animals in vivoHippocampus, 2007
- Contribution of NR2A and NR2B NMDA subunits to bidirectional synaptic plasticity in the hippocampus in vivoHippocampus, 2006
- NR2B-containing N-methyl-D-aspartate subtype glutamate receptors regulate the acute stress effect on hippocampal long-term potentiation/long-term depression in vivoNeuroReport, 2006
- Zinc Modulates Bidirectional Hippocampal Plasticity by Effects on NMDA ReceptorsJournal of Neuroscience, 2006
- Impaired Memory Retrieval after Psychosocial Stress in Healthy Young MenJournal of Neuroscience, 2005
- THE AMYGDALA MODULATES THE CONSOLIDATION OF MEMORIES OF EMOTIONALLY AROUSING EXPERIENCESAnnual Review of Neuroscience, 2004
- Glucocorticoid‐induced impairment of declarative memory retrieval is associated with reduced blood flow in the medial temporal lobeEuropean Journal of Neuroscience, 2003
- The Corticosteroid Receptor Hypothesis of DepressionNeuropsychopharmacology, 2000
- In Vivo Protein Transduction: Delivery of a Biologically Active Protein into the MouseScience, 1999
- Control of Memory Formation Through Regulated Expression of a CaMKII TransgeneScience, 1996