Determination of Ofloxacin, A New Oxazine Derivative in Human Serum, Urine, and Bile by High-Performance Liquid Chromatography
- 1 September 1986
- journal article
- research article
- Published by Informa UK Limited in Journal of Liquid Chromatography
- Vol. 9 (11), 2539-2547
- https://doi.org/10.1080/01483918608076882
Abstract
A simple and precise high-performance liquid procedure has been developed for the determination of Ofloxacin (DL-8280), a new oxazine derivative in human serum, urine and bile using Norfloxacin as internal standard. The work-up procedure involves a chemical extraction step followed by isocratic chromatography on a anion-exchange analytical column, with ultraviolet detection. The run time for the assay was 11.5 minutes.This publication has 2 references indexed in Scilit:
- Comparison of the antibacterial in vitro and in vivo activity of ofloxacin (HOE 280 DL 8280) and nalidixic acid analoguesEuropean Journal of Clinical Microbiology & Infectious Diseases, 1983
- In vitro and in vivo activity of DL-8280, a new oxazine derivativeAntimicrobial Agents and Chemotherapy, 1982