Antioxidant and antiinflammatory activities of xanthorrhizol in hippocampal neurons and primary cultured microglia
- 4 November 2005
- journal article
- research article
- Published by Wiley in Journal of Neuroscience Research
- Vol. 82 (6), 831-838
- https://doi.org/10.1002/jnr.20692
Abstract
Xanthorrhizol, a natural sesquiterpenoid isolated from the rhizome of Curcuma xanthorrhiza Roxb (Zingiberaceae), has antibacterial activities and protective effects against cisplatin‐induced hepatotoxicity. In this study, we investigated the activities of xanthorrhizol as an antioxidant or antiinflammatory agent using neuronal and microglial cells. Xanthorrhizol had potent neuroprotective effects on glutamate‐induced neurotoxicity and reactive oxygen species (ROS) generation in the murine hippocampal HT22 cell line. Also, xanthorrhizol inhibited H2O2‐induced lipid peroxidation in rat brain homogenates. The properties of xanthorrhizol as an antiinflammatory agent were investigated in microglial activation by lipopolysaccharide. It reduced the expression of cyclooxygenase‐2 and the inducible nitric oxide synthase, which consequently resulted in the reduction of nitric oxide. The production of proinflammatory cytokines, such as interleukin‐6 and tumor necrosis factor‐α in activated microglial cells, was reduced by xanthorrhizol. These results suggest that xanthorrhizol could be an effective candidate for the treatment of Alzheimer's disease‐ and other neurological disease‐related ROS and inflammation.Keywords
This publication has 32 references indexed in Scilit:
- Anti-oxidant and anti-inflammatory activities of macelignan in murine hippocampal cell line and primary culture of rat microglial cellsBiochemical and Biophysical Research Communications, 2005
- Mercury-induced apoptosis and necrosis in murine macrophages: role of calcium-induced reactive oxygen species and p38 mitogen-activated protein kinase signalingToxicology and Applied Pharmacology, 2004
- Abrogation of cisplatin-induced hepatotoxicity in mice by xanthorrhizol is related to its effect on the regulation of gene transcriptionToxicology and Applied Pharmacology, 2004
- Oxidative neuronal death caused by glutamate uptake inhibition in cultured hippocampal neuronsJournal of Neuroscience Research, 2002
- Gene expression profiling of 12633 genes in Alzheimer hippocampal CA1: Transcription and neurotrophic factor down‐regulation and up‐regulation of apoptotic and pro‐inflammatory signalingJournal of Neuroscience Research, 2002
- Antioxidant strategies for Alzheimer's diseaseProceedings of the Nutrition Society, 2002
- Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NF-κB activationMutation Research, 2001
- Xanthorrhizol: A Potential Antibacterial Agent fromCurcuma xanthorrhizaagainstStreptococcus mutansPlanta Medica, 2000
- Vitamin E protects nerve cells from amyloid βprotein toxicityBiochemical and Biophysical Research Communications, 1992
- Aging: A Theory Based on Free Radical and Radiation ChemistryJournal of Gerontology, 1956