A linear complexity phasing method for thousands of genomes
Top Cited Papers
- 4 December 2011
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Methods
- Vol. 9 (2), 179-181
- https://doi.org/10.1038/nmeth.1785
Abstract
Human-disease etiology can be better understood with phase information about diploid sequences. We present a method for estimating haplotypes, using genotype data from unrelated samples or small nuclear families, that leads to improved accuracy and speed compared to several widely used methods. The method, segmented haplotype estimation and imputation tool (SHAPEIT), scales linearly with the number of haplotypes used in each iteration and can be run efficiently on whole chromosomes.Keywords
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