Potential of the Dietary Antioxidants Resveratrol and Curcumin in Prevention and Treatment of Hematologic Malignancies
Open Access
- 12 October 2010
- Vol. 15 (10), 7035-7074
- https://doi.org/10.3390/molecules15107035
Abstract
Despite considerable improvements in the tolerance and efficacy of novel chemotherapeutic agents, the mortality of hematological malignancies is still high due to therapy relapse, which is associated with bad prognosis. Dietary polyphenolic compounds are of growing interest as an alternative approach, especially in cancer treatment, as they have been proven to be safe and display strong antioxidant properties. Here, we provide evidence that both resveratrol and curcumin possess huge potential for application as both chemopreventive agents and anticancer drugs and might represent promising candidates for future treatment of leukemia. Both polyphenols are currently being tested in clinical trials. We describe the underlying mechanisms, but also focus on possible limitations and how they might be overcome in future clinical use – either by chemically synthesized derivatives or special formulations that improve bioavailability and pharmacokinetics.Keywords
This publication has 240 references indexed in Scilit:
- RETRACTED: Cyclodextrin-complexed curcumin exhibits anti-inflammatory and antiproliferative activities superior to those of curcumin through higher cellular uptakeBiochemical Pharmacology, 2010
- Regulation of SIRT1 in cellular functions: Role of polyphenolsArchives of Biochemistry and Biophysics, 2010
- Bisdemethylcurcumin and structurally related hispolon analogues of curcumin exhibit enhanced prooxidant, anti-proliferative and anti-inflammatory activities in vitroBiochemical Pharmacology, 2010
- RETRACTED: Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivoBiochemical Pharmacology, 2010
- RETRACTED: Curcumin potentiates the antitumor effects of gemcitabine in an orthotopic model of human bladder cancer through suppression of proliferative and angiogenic biomarkersBiochemical Pharmacology, 2010
- Resveratrol, a multitargeted agent, can enhance antitumor activity of gemcitabine in vitro and in orthotopic mouse model of human pancreatic cancerInternational Journal of Cancer, 2009
- Chemopreventive potential of curcumin in prostate cancerGenes & Nutrition, 2009
- Free radicals and antioxidants in normal physiological functions and human diseaseThe International Journal of Biochemistry & Cell Biology, 2007
- CURCUMIN: THE INDIAN SOLID GOLDAdvances in Experimental Medicine and Biology, 2006
- Transcriptional regulation via cysteine thiol modification: A novel molecular strategy for chemoprevention and cytoprotectionMolecular Carcinogenesis, 2006