Fludarabine Compared with Chlorambucil as Primary Therapy for Chronic Lymphocytic Leukemia
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- 14 December 2000
- journal article
- clinical trial
- Published by Massachusetts Medical Society in The New England Journal of Medicine
- Vol. 343 (24), 1750-1757
- https://doi.org/10.1056/nejm200012143432402
Abstract
Fludarabine is an effective treatment for chronic lymphocytic leukemia that does not respond to initial treatment with chlorambucil. We compared the efficacy of fludarabine with that of chlorambucil in the primary treatment of chronic lymphocytic leukemia.Keywords
This publication has 14 references indexed in Scilit:
- Chlorambucil in Indolent Chronic Lymphocytic LeukemiaThe New England Journal of Medicine, 1998
- Multicentre prospective randomised trial of fludarabine versus cyclophosphamide, doxorubicin, and prednisone (CAP) for treatment of advanced-stage chronic lymphocytic leukaemiaThe Lancet, 1996
- Long-term follow-up of patients with chronic lymphocytic leukemia treated with fludarabine as a single agentBlood, 1993
- Fludarabine: a new agent with marked cytoreductive activity in untreated chronic lymphocytic leukemia.Journal of Clinical Oncology, 1991
- Fludarabine: a new agent with major activity against chronic lymphocytic leukemiaBlood, 1989
- Guidelines for clinical protocols for chronic lymphocytic leukemia: Recommendations of the national cancer institute‐sponsored working groupAmerican Journal of Hematology, 1988
- Discrete Sequential Boundaries for Clinical TrialsBiometrika, 1983
- Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. Analysis and examplesBritish Journal of Cancer, 1977
- Clinical staging of chronic lymphocytic leukemiaBlood, 1975
- Nonparametric Estimation from Incomplete ObservationsJournal of the American Statistical Association, 1958