Short telomeres in an oral precancerous lesion: Q‐FISH analysis of leukoplakia
- 29 November 2011
- journal article
- research article
- Published by Wiley in Journal of Oral Pathology & Medicine
- Vol. 41 (5), 372-378
- https://doi.org/10.1111/j.1600-0714.2011.01120.x
Abstract
J Oral Pathol Med (2012) 41: 372–378 Objectives: A precancerous condition is a lesion that, if left untreated, leads to cancer or can be induced to become malignant. In the oral region, leukoplakia is a lesion that has been regarded as precancerous. In cases of oral carcinoma, we have frequently noticed that a type of leukoplakia histologically demonstrating hyper‐orthokeratosis and mild atypia (ortho‐keratotic dysplasia; OKD) is often associated with carcinoma, either synchronously or metachronously. Therefore, we consider OKD‐type leukoplakia to be a true precancerous lesion. Materials and Methods: In an attempt to clarify the relationship between OKD as a precancerous condition in the oral mucosa and telomere length, we estimated telomere lengths in this type of leukoplakia using quantitative fluorescence in situ hybridization, and also quantified the frequency of anaphase–telophase bridges (ATBs) in comparison with squamous cell carcinoma in situ (CIS) and the background tissues of CIS and OKD. Results: Ortho‐keratotic dysplasia was frequently associated with squamous cell carcinoma (45.0%) and showed significantly shorter telomeres than normal control epithelium, CIS, or the background of CIS or OKD. The frequency of ATBs was much higher in OKD than in control epithelium or CIS. Conclusion: Ortho‐keratotic dysplasia appears to be frequently associated with carcinoma, chromosomal instability, and excessively shortened telomeres, not only in the lesion itself but also in the surrounding background. Therefore, when this type of leukoplakia is recognized in the oral region, strict follow‐up for oral squamous cell carcinoma is necessary, focusing not only on the areas of leukoplakia, but also the surrounding background.Keywords
This publication has 19 references indexed in Scilit:
- Alcoholics show reduced telomere length in the oesophagusThe Journal of Pathology, 2010
- Q‐FISH analysis of telomere and chromosome instability in the oesophagus with and without squamous cell carcinoma in situThe Journal of Pathology, 2010
- Telomere lengths in the oral epithelia with and without carcinomaEuropean Journal of Cancer, 2010
- Squamous Intraepithelial Neoplasia of the Upper Aerodigestive TractPublished by Elsevier BV ,2009
- Basal cells have longest telomeres measured by tissue Q-FISH method in lingual epitheliumExperimental Gerontology, 2008
- Telomere instability and cancerBiochimie, 2008
- Shelterin: the protein complex that shapes and safeguards human telomeresGenes & Development, 2005
- Oral erythroplakia—a reviewOral Oncology, 2005
- Comparative Analysis of Telomere Lengths and Erosion with Age in Human Epidermis and Lingual EpitheliumJournal of Investigative Dermatology, 2002
- The age of cancerNature, 2000