Hepatic Regeneration and Erythropoietin Production in the Rat
- 15 April 1977
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 196 (4287), 301-302
- https://doi.org/10.1126/science.847471
Abstract
The regenerating liver produces erythropoietin in response to hypoxia. The amounts of erythropoietin produced in animals subjected to hepatectomy are significantly higher than those observed in sham-operated animals. Hepatic erythropoietin production appears to be dependent upon the stage of regeneration with the highest levels being produced during the period of greatest proliferation and increase in liver mass.Keywords
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