The Nephrotoxicity of Antimicrobial Agents

Abstract

The SulfonamidesCrystallization leading to obstructive nephropathy, allergic and hypersensitivity reactions, precipitation of hemoglobin casts secondary to drug-induced hemolysis and an intrinsic toxic effect have all been reported as secondary to sulfonamide therapy. Although the frequency of nephrotoxicity due to sulfonamides has markedly decreased, this class of drugs remains potentially dangerous to the kidney.Sulfonamides are partly filtered, partly reabsorbed and secreted, depending on the nature of the individual drugs.²¹⁸ Solubility in the urine depends on the drug concentration (a function of the plasma concentration and state of hydration of the patient), the urinary pH and temperature and the intrinsic . . .