Clinical and Experimental Studies of Autoimmune Inner Ear Disease
- 1 January 2002
- journal article
- Published by Informa UK Limited in Acta Oto-Laryngologica
- Vol. 122 (5), 10-14
- https://doi.org/10.1080/00016480260094901
Abstract
Otolaryngologists have long sought to identify causes of sensorineural hearing loss that could be reversed by medical treatment. An increasing amount of clinical and experimental evidence indicates that this postulated entity is related to autoimmune inner ear disease. Because of the lack of well-defined detection methods for identifying autoimmune processes within the human inner ear and the fact that it is one of the few organs of the body not amenable to diagnostic biopsy there has been great interest in developing animal models that mimic clinical entities. Different models will be presented in this paper. The results of these studies should provide sufficient evidence to establish a clear position in mainstream immunology for the entity of autoimmune inner ear disease.Keywords
This publication has 13 references indexed in Scilit:
- Sudden Sensorineural Hearing LossJAMA Otolaryngology–Head & Neck Surgery, 2001
- Role of S-100β as potential autoantigen in an autoimmune disease of the inner earJournal of Neuroimmunology, 1999
- Vogt-Koyanagi-Harada syndromeSurvey of Ophthalmology, 1995
- Experimental autoimmune panencephalitis and uveoretinitis transferred to the Lewis rat by T lymphocytes specific for the S100 beta molecule, a calcium binding protein of astroglia.The Journal of Experimental Medicine, 1994
- Defining criteria for autoimmune diseases (Witebsky's postulates revisited)Immunology Today, 1993
- Role of Lymphokines in the Immune Response of the Inner EarActa Oto-Laryngologica, 1989
- The endolymphatic sac: its importance in inner ear immune responsesThe Laryngoscope, 1986
- Sympathetic Ophthalmia following VitrectomyAmerican Journal of Ophthalmology, 1982
- Sympathetic OphthalmiaAmerican Journal of Ophthalmology, 1981
- The Efficacy of Steroids in the Treatment of Idiopathic Sudden Hearing Loss: A Double-blind Clinical StudyJAMA Otolaryngology–Head & Neck Surgery, 1980