The Promise of Patient-Derived Xenografts: The Best Laid Plans of Mice and Men
- 30 September 2012
- journal article
- editorial
- Published by American Association for Cancer Research (AACR) in Clinical Cancer Research
- Vol. 18 (19), 5160-5162
- https://doi.org/10.1158/1078-0432.ccr-12-2408
Abstract
Compared with xenografts from previously established cell lines, patient-derived xenografts may more faithfully recapitulate the molecular diversity, cellular heterogeneity, and histology seen in patient tumors, although other limitations of murine models remain. The ability of these models to inform clinical development and answer mechanistic questions will determine their ultimate use. Clin Cancer Res; 18(19); 5160–2. ©2012 AACR.Keywords
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This publication has 11 references indexed in Scilit:
- Characterization of a Large Panel of Patient-Derived Tumor Xenografts Representing the Clinical Heterogeneity of Human Colorectal CancerClinical Cancer Research, 2012
- Imageable fluorescent metastasis resulting in transgenic GFP mice orthotopically implanted with human-patient primary pancreatic cancer specimens.2012
- Tumor grafts derived from women with breast cancer authentically reflect tumor pathology, growth, metastasis and disease outcomesNature Medicine, 2011
- A Pilot Clinical Study of Treatment Guided by Personalized Tumorgrafts in Patients with Advanced CancerMolecular Cancer Therapeutics, 2011
- PI-3-Kinase Inhibitors in Colorectal CancerCurrent Cancer Drug Targets, 2011
- Finding the tumor copycat: Therapy fails, patients don'tNature Medicine, 2010
- Generation of orthotopic and heterotopic human pancreatic cancer xenografts in immunodeficient miceNature Protocols, 2009
- The use of xenograft models for the selection of cancer treatments with the EGFR as an exampleCritical Reviews in Oncology/Hematology, 2007
- Anticancer drug response and expression of molecular markers in early-passage xenotransplanted colon carcinomasEuropean Journal of Cancer, 2004
- In vitro assays of chemotherapeutic sensitivity.1985