Hollow ferric-tannic acid nanocapsules with sustained O2and ROS induction for synergistic tumor therapy
- 21 July 2020
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Biomaterials Science
- Vol. 8 (14), 3844-3855
- https://doi.org/10.1039/d0bm00533a
Abstract
Nanoparticles presenting promoted catalytic activity, oxygen induction and loading capability are in high demand for effective synergistic tumor therapy. Herein, ferric-tannic acid complex nanocapsules with fine hollow microstructure (HFe-TA) are synthesized and loaded with a photosensitizer (indocyanine green, ICG) for synergistic tumor therapy. In acidic environment, ICG@HFe-TA decomposes and releases Fe(3+)ions, TA and ICG molecules. Fe3+, with low catalytic activity, is effectively converted into highly catalytic Fe(2+)by the reductant TA, enabling promoted efficacy of & x2d9;OH induction. More importantly, the ROS (O-1(2)) induction by ICG is significantly enhanced under 808 nm laser irradiation due to the O(2)byproduct of Fe3+/Fe(2+)conversion. In consequence, the ICG@HFe-TA nanoparticles exhibit considerablein vitroandin vivotumor inhibition owing to the combined effect of & x2d9;OH and(1)O(2)induced intracellularly. This study has therefore demonstrated a potential platform enabling combined photodynamic and chemodynamic therapy with high efficacy.Funding Information
- National Natural Science Foundation of China (51672247, 51902288)
- Ministry of Education of the People's Republic of China (B16043)
- Fundamental Research Funds for the Central Universities
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