Baroreflex: A New Therapeutic Target in Human Stroke?
- 1 December 2009
- journal article
- review article
- Published by Ovid Technologies (Wolters Kluwer Health) in Stroke
- Vol. 40 (12), e678-82
- https://doi.org/10.1161/strokeaha.109.565838
Abstract
Background and Purpose— Autonomic dysfunction, including increased sympathetic drive and blunted baroreflex, has repeatedly been observed in acute stroke. Of clinical importance is that the stroke-related autonomic imbalance seems to be linked to worse outcome after stroke. Here, we discuss the role of baroreflex impairment in acute stroke and its possible pathophysiological and therapeutic relevance. Summary of Review— Possible mechanisms linking baroreflex impairment with unfavorable outcome in stroke may include increased cardiovascular morbidity and mortality, promotion of secondary brain injury due to local inflammation, hyperglycemia, or altered cerebral perfusion. Conclusions— We suggest therefore that the modifying of autonomic functions may have important therapeutic implications in acute ischemic as well as in hemorrhagic stroke.This publication has 56 references indexed in Scilit:
- Subacute perihematomal edema in intracerebral hemorrhage is associated with impaired blood pressure regulationJournal of the Neurological Sciences, 2009
- Relationship Between Hyperacute Blood Pressure and Outcome After Ischemic StrokeStroke, 2009
- Arterial baroreflex function is an important determinant of acute cerebral ischemia in rats with middle cerebral artery occlusionLife Sciences, 2008
- Cerebrogenic cardiac arrhythmias:Clinical Autonomic Research, 2006
- Dynamic Cerebral Autoregulation in Acute Lacunar and Middle Cerebral Artery Territory Ischemic StrokeStroke, 2005
- Baroreflex Sensitivity Is Impaired in Bilateral Carotid AtherosclerosisStroke, 2005
- Abnormalities in cardiac baroreceptor sensitivity in acute ischaemic stroke patients are related to aortic stiffnessClinical Science, 2005
- Long-term effects of unilateral carotid endarterectomy on arterial baroreflex functionClinical Autonomic Research, 2004
- High Blood Pressure in Acute Stroke and Subsequent OutcomeHypertension, 2004
- Hyperglycemia Exacerbates Brain Edema and Perihematomal Cell Death After Intracerebral HemorrhageStroke, 2003