Increased PD‐1 expression on CD4+ and CD8+ T cells is involved in immune evasion in gastric cancer
- 5 November 2012
- journal article
- research article
- Published by Wiley in Journal of Surgical Oncology
- Vol. 107 (5), 517-522
- https://doi.org/10.1002/jso.23281
Abstract
Background Co‐signaling molecules play an important role in T cells. Programmed death‐1 (PD‐1) is an immunoinhibitory receptor and its overexpression on T cells appears to be involved in immune evasion in cancer patients. The present study was designed to investigate PD‐1 expression on T cells and its relationship with immune evasion in gastric cancer patients. Methods PD‐1 expression on CD4+ and CD8+ T cells obtained from peripheral blood mononuclear cells (PBMC), normal gastric mucosa, and gastric cancer tissue was evaluated by multicolor flow cytometry. Results PD‐1 expression on CD4+ and CD8+ T cells from gastric cancer patients was significantly higher than that from normal controls. PD‐1 expression on CD4+ and CD8+ T cells was related to disease progression. Furthermore, PD‐1 expression on CD4+ and CD8+ T cells from gastric cancer tissue was significantly higher than that from normal gastric mucosa and PBMC. PD‐1 positive CD4+ and CD8+ T cells produced significantly less IFN‐gamma than PD‐1 negative CD4+ and CD8+ T cells. Conclusions Upregulation of PD‐1 on both CD4+ and CD8+ T cells may be, in part, responsible for immune evasion in gastric cancer patients. J. Surg. Oncol. 2013;107:517–522.Keywords
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