Human Immunodeficiency Virus Type 1-Specific Immunity after Genetic Immunization Is Enhanced by Modification of Gag and Pol Expression
Open Access
- 15 May 2001
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 75 (10), 4947-4951
- https://doi.org/10.1128/jvi.75.10.4947-4951.2001
Abstract
Immunity to human immunodeficiency virus virion-like structures or a polyprotein has been examined after DNA immunization with Rev-independent expression vectors. A Gag-Pol fusion protein stimulated cytotoxic T lymphocyte and antibody responses to Gag and Pol, while a Gag-Pol pseudoparticle did not elicit substantial Pol responses. This fusion protein may be useful for AIDS vaccines.Keywords
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