Mycoplasma pneumoniaepneumonia in children
Open Access
- 1 January 2012
- journal article
- Published by Korean Pediatric Society in Korean Journal of Pediatrics
- Vol. 55 (2), 42-47
- https://doi.org/10.3345/kjp.2012.55.2.42
Abstract
Mycoplasma pneumoniae (MP), the smallest self-replicating biological system, is a common cause of upper and lower respiratory tract infections, leading to a wide range of pulmonary and extra-pulmonary manifestations. MP pneumonia has been reported in 10 to 40% of cases of community-acquired pneumonia and shows an even higher proportion during epidemics. MP infection is endemic in larger communities of the world with cyclic epidemics every 3 to 7 years. In Korea, 3 to 4-year cycles have been observed from the mid-1980s to present. Although a variety of serologic assays and polymerase chain reaction (PCR) techniques are available for the diagnosis of MP infections, early diagnosis of MP pneumonia is limited by the lack of immunoglobulin (Ig) M antibodies and variable PCR results in the early stages of the infection. Thus, short-term paired IgM serologic tests may be mandatory for an early and definitive diagnosis. MP infection is usually a mild and self-limiting disease without specific treatment, and if needed, macrolides are generally used as a first-choice drug for children. Recently, macrolide-resistant MP strains have been reported worldwide. However, there are few reports of apparent treatment failure, such as progression of pneumonia to acute respiratory distress syndrome despite macrolide treatment. The immunopathogenesis of MP pneumonia is believed to be a hyperimmune reaction of the host to the insults from MP infection, including cytokine overproduction and immune cell activation (T cells). In this context, immunomodulatory treatment (corticosteroids or/and intravenous Ig), in addition to antibiotic treatment, might be considered for patients with severe infection.Keywords
This publication has 49 references indexed in Scilit:
- Domain Analysis of Protein P30 in Mycoplasma pneumoniae Cytadherence and Gliding MotilityJournal of Bacteriology, 2011
- Cytoadherence‐dependent induction of inflammatory responses by Mycoplasma pneumoniaeImmunology, 2011
- Hyperactive immune cells (T cells) may be responsible for acute lung injury in influenza virus infections: A need for early immune-modulators for severe casesMedical Hypotheses, 2011
- Two unexpected phenomena in macrolide-resistant Mycoplasma pneumoniae infection in Japan and the unique biological characteristics of Mycoplasma pneumoniaeJournal of Infection and Chemotherapy, 2011
- Variation in Colonization, ADP-Ribosylating and Vacuolating Cytotoxin, and Pulmonary Disease Severity among Mycoplasma pneumoniae StrainsAmerican Journal of Respiratory and Critical Care Medicine, 2010
- Difference of clinical features in childhood Mycoplasma pneumoniae pneumoniaBMC Pediatrics, 2010
- Pathogen Recognition and Inflammatory Signaling in Innate Immune DefensesClinical Microbiology Reviews, 2009
- Mycoplasma lipoproteins and Toll-like receptorsJournal of Zhejiang University-SCIENCE B, 2009
- The Impact of Steroids Given with Macrolide Therapy on ExperimentalMycoplasma pneumoniaeRespiratory InfectionThe Journal of Infectious Diseases, 2008
- Epidemiology, clinical manifestations, pathogenesis and laboratory detection ofMycoplasma pneumoniaeinfections: Figure 1FEMS Microbiology Reviews, 2008