Association Between Sexual Precocity and Alleles ofKISS-1andGPR54Genes in Goats
- 19 June 2009
- journal article
- research article
- Published by Taylor & Francis Ltd in Animal Biotechnology
- Vol. 20 (3), 172-176
- https://doi.org/10.1080/10495390903004493
Abstract
KISS-1 and GPR54 were regarded as key regulators for the puberty onset and fundamental gatekeepers of sexual maturation in mammals. To explore the possible association between variations in KISS-1 and GPR54 with sexual precocity, mutation screening of exon 1 of KISS-1 and exon 1, exon 3, and partial exon 5 of GPR54 was performed in a sexual precocious breed (Jining Grey goats) and sexual late-maturing breeds (Inner Mongolia Cashmere, Angora, and Boer goats) by PCR-SSCP. The results showed that five novel mutations were identified in exon 1 and partial exon 5 of GPR54 including C96 T, T173C, G176A, G825A, and C981 T. The Jining Grey goats with genotype BB or AB had 1.07 (P < 0.05) or 0.40 (P < 0.05) kids more than those with AA. The Jining Grey goats with genotype DD or CD had 1.80 (P < 0.05) or 0.55 (P < 0.05) kids more than CC, respectively. The present study preliminarily showed an association between alleles B and D of GPR54 with high litter size and sexual precocity in Jining Grey goats.Keywords
This publication has 14 references indexed in Scilit:
- Characterization of the porcine Kisspeptins receptor gene and evaluation as candidate for timing of puberty in sowsJournal of Animal Breeding and Genetics, 2008
- Association Between PCR-SSCP of Bone Morphogenetic Protein 15 Gene and Prolificacy in Jining Grey GoatsAnimal Biotechnology, 2007
- Association study of the polymorphisms in the KISS1 gene with central precocious puberty in Chinese girlsActa Endocrinologica, 2007
- Coding sequence analysis of GNRHR and GPR54 in patients with congenital and adult-onset forms of hypogonadotropic hypogonadismActa Endocrinologica, 2006
- Activation of Gonadotropin-Releasing Hormone Neurons by Kisspeptin as a Neuroendocrine Switch for the Onset of PubertyJournal of Neuroscience, 2005
- Two Novel Missense Mutations in G Protein-Coupled Receptor 54 in a Patient with Hypogonadotropic HypogonadismJournal of Clinical Endocrinology & Metabolism, 2005
- Kisspeptin Activation of Gonadotropin Releasing Hormone Neurons and Regulation of KiSS-1 mRNA in the Male RatNeuroendocrinology, 2004
- TheGPR54Gene as a Regulator of PubertyThe New England Journal of Medicine, 2003
- AXOR12, a Novel Human G Protein-coupled Receptor, Activated by the Peptide KiSS-1Published by Elsevier BV ,2001
- The improved Boer goatSmall Ruminant Research, 2000