Efficacy and Safety of Carbon Ion Radiotherapy in Bone and Soft Tissue Sarcomas
- 15 November 2002
- journal article
- research article
- Published by American Society of Clinical Oncology (ASCO) in Journal of Clinical Oncology
- Vol. 20 (22), 4466-4471
- https://doi.org/10.1200/jco.2002.10.050
Abstract
PURPOSE: To evaluate the tolerance for and effectiveness of carbon ion radiotherapy in patients with unresectable bone and soft tissue sarcomas. PATIENTS AND METHODS: We conducted a phase I/II dose escalation study of carbon ion radiotherapy. Fifty-seven patients with 64 sites of bone and soft tissue sarcomas not suited for resection received carbon ion radiotherapy. Tumors involved the spine or paraspinous soft tissues in 19 patients, pelvis in 32 patients, and extremities in six patients. The total dose ranged from 52.8 to 73.6 gray equivalent (GyE) and was administered in 16 fixed fractions over 4 weeks (3.3 to 4.6 GyE/fraction). The median tumor size was 559 cm3 (range, 20 to 2,290 cm3). The minimum follow-up was 18 months. RESULTS: Seven of 17 patients treated with the highest total dose of 73.6 GyE experienced Radiation Therapy Oncology Group grade 3 acute skin reactions. Dose escalation was then halted at this level. No other severe acute reactions (grade > 3) were observed in this series. The overall local control rates were 88% and 73% at 1 year and 3 years of follow-up, respectively. The median survival time was 31 months (range, 2 to 60 months), and the 1- and 3-year overall survival rates were 82% and 46%, respectively. CONCLUSION: Carbon ion radiotherapy seems to be a safe and effective modality in the management of bone and soft tissue sarcomas not eligible for surgical resection, providing good local control and offering a survival advantage without unacceptable morbidity.Keywords
This publication has 16 references indexed in Scilit:
- Fast neutron radiotherapy for soft tissue and cartilaginous sarcomas at high risk for local recurrenceInternational Journal of Radiation Oncology*Biology*Physics, 2001
- Osteosarcoma of the pelvisThe Journal of Bone and Joint Surgery, 1999
- Osteosarcoma of the PelvisClinical Orthopaedics and Related Research, 1998
- Performance of HIMACNuclear Physics A, 1995
- Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European organization for research and treatment of cancer (EORTC)International Journal of Radiation Oncology*Biology*Physics, 1995
- Tumors of the connective and supporting tissuesRadiotherapy and Oncology, 1995
- Locally challenging osteo- and chondrogenic tumors of the axial skeleton: Results of combined proton and photon radiation therapy using three-dimensional treatment planningInternational Journal of Radiation Oncology*Biology*Physics, 1995
- Neon ion radiotherapy: Results of the phase I/II clinical trialInternational Journal of Radiation Oncology*Biology*Physics, 1991
- Heavy-Ion Radiobiology: Cellular StudiesPublished by Elsevier BV ,1984
- Nonparametric Estimation from Incomplete ObservationsJournal of the American Statistical Association, 1958