Environmental risk factors for haemorrhagic fever with renal syndrome in a French new epidemic area
- 8 September 2010
- journal article
- research article
- Published by Cambridge University Press (CUP) in Epidemiology and Infection
- Vol. 139 (6), 867-874
- https://doi.org/10.1017/s0950268810002062
Abstract
In France, haemorrhagic fever with renal syndrome (HFRS) is endemic along the Belgian border. However, this rodent-borne zoonosis caused by the Puumala virus has recently spread south to the Franche-Comté region. We investigated the space–time distribution of HFRS and evaluated the influence of environmental factors that drive the hantavirus reservoir abundance and/or the disease transmission in this area. A scan test clearly indicated space–time clustering, highlighting a single-year (2005) epidemic in the southern part of the region, preceded by a heat-wave 2 years earlier. A Bayesian regression approach showed an association between a variable reflecting biomass (normalized difference vegetation index) and HFRS incidence. The reasons why HFRS cases recently emerged remain largely unknown, and climate parameters alone do not reliably predict outbreaks. Concerted efforts that combine reservoir monitoring, surveillance, and investigation of human cases are warranted to better understand the epidemiological patterns of HFRS in this area.Keywords
This publication has 26 references indexed in Scilit:
- Relating increasing hantavirus incidences to the changing climate: the mast connectionInternational Journal of Health Geographics, 2009
- Landscape Elements and Hantaan Virus–related Hemorrhagic Fever with Renal Syndrome, People’s Republic of ChinaEmerging Infectious Diseases, 2007
- Genetic evidence of Puumala and Tula Hantaviruses in rodents in the Jura region, France – preliminary resultsEurosurveillance, 2007
- Environmental conditions and Puumala virus transmission in BelgiumInternational Journal of Health Geographics, 2007
- Determinants of the geographic distribution of Puumala virus and Lyme borreliosis infections in BelgiumInternational Journal of Health Geographics, 2007
- Prolonged survival of Puumala hantavirus outside the host: evidence for indirect transmission via the environmentJournal of General Virology, 2006
- Hantavirus Infections in EuropeThe Lancet Infectious Diseases, 2003
- WinBUGS - A Bayesian modelling framework: Concepts, structure, and extensibilityStatistics and Computing, 2000
- Dynamics of Puumala hantavirus infection in naturally infected bank voles (Clethrinomys glareolus)Archiv für die gesamte Virusforschung, 1999
- Factors influencing the distribution of the bank vole in forest habitatsMammal Research, 1994