A Concise Review of the Epidemiology and Diagnostics of Rickettsioses: Rickettsia and Orientia spp
- 1 August 2018
- journal article
- review article
- Published by American Society for Microbiology in Journal of Clinical Microbiology
- Vol. 56 (8)
- https://doi.org/10.1128/jcm.01728-17
Abstract
Rickettsioses are globally distributed and caused by the family Rickettsiaceae, which comprise a diverse and expanding list of organisms. These include two genera, Rickettsia and Orientia. Serology has been traditionally the mainstay of diagnosis, although this has been limited by cross-reactions among closely related members and diminished sensitivity/utility in the acute phase of illness. Other techniques, such as nucleic acid amplification tests using blood specimens or tissue swabs/biopsy specimens, sequencing, and mass spectrometry, have emerged in recent years for both pathogen and vector identification. This paper provides a concise review of the rickettsioses and the traditional and newer technologies available for their diagnosis.Keywords
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