Voltammetric behavior of some fluorinated quinolone antibacterial agents and their differential pulse voltammetric determination in drug formulations and urine samples using a β-cyclodextrin-modified carbon-paste electrode
- 1 February 2007
- journal article
- Published by Pleiades Publishing Ltd in Journal of Analytical Chemistry
- Vol. 62 (2), 168-175
- https://doi.org/10.1134/s1061934807020128
Abstract
A voltammetric determination of ofloxacin (OF), norfloxacin (NF), gatifloxacin (GF), and lomefloxacin (LF) at a β-cyclodextrin-modified carbon-paste electrode (CDMCPE) is described. A large increase in the peak currents was observed in cyclic voltammetry (CV) and differential pulse voltammetry (DPV) of OF, NF, GF, and LF at CDMCPE compared with a bare carbon-paste electrode (CPE). These increases in the peak currents were attributed to the complex formation of the quinone group of the drugs with β-cyclodextrin. CV studies indicate that the process is irreversible and adsorption-controlled. The experimental parameters which influence the peak current responses of OF, NF, GF, and LF were studied. The reduction peak currents of OF, NF, GF, and LF change linearly over the common concentration range from 3.2 × 10−8 to 2 × 10−5 M, with a common correlation coefficient and limit of detection of 0.9995 and 2.4 × 10−8 M, respectively, in pH 4.0 Britton-Robinson (BR) buffer at an accumulation time of 160 s. The interference of metal ions in the peak current response was also studied. The modified electrode exhibited good sensitivity and stability. The proposed method was applied to the determination of OF, NF, GF, and LF in both commercially available drugs and spiked human urine samples.Keywords
This publication has 20 references indexed in Scilit:
- Carbon Paste Electrodes in Modern ElectroanalysisCritical Reviews in Analytical Chemistry, 2001
- Differential-pulse adsorptive stripping voltammetric determination of the antibacterial lomefloxacinJournal of Pharmaceutical and Biomedical Analysis, 2001
- Determination of gatifloxacin in human plasma by liquid chromatography/electrospray tandem mass spectrometryRapid Communications in Mass Spectrometry, 2001
- Determination of gatifloxacin in human serum and urine by HPLCChromatographia, 2000
- Differential pulse polarographic determination of ofloxacin in pharmaceuticals and biological fluidsTalanta, 1998
- Polarographic behaviour and determination of norfloxacin in tabletsAnalytica Chimica Acta, 1994
- Simultaneous determination of ofloxacin, norfloxacin and ciprofloxacin in human hair by high-performance liquid chromatography and fluorescence detectionJournal of Chromatography B: Biomedical Sciences and Applications, 1994
- Spectrophotometric and Spectrofluorimetric Determination of OfloxacinSpectroscopy Letters, 1992
- Chemically modified carbon paste electrodes in voltammetric analysisElectroanalysis, 1990
- Determination of Pantothenic Acid in Multivitamin Pharmaceutical Preparations by Reverse-Phase High-Performance Liquid ChromatographyJournal of Pharmaceutical Sciences, 1984