Ag(I)N bond-containing compound showing wide spectra in effective antimicrobial activities: Polymeric silver(I) imidazolate
- 1 October 1997
- journal article
- research article
- Published by Elsevier BV in Journal of Inorganic Biochemistry
- Vol. 68 (1), 39-44
- https://doi.org/10.1016/s0162-0134(97)00006-8
Abstract
A neutral, Ag(I)N bonding compound, polymeric silver(I)-imidazolate [Ag(imd)]n (1) consisting of Ag+: imd = 1:1 (Himd = imidazole, C3H4N2), whowed wide spectra in effective antimicrobial activities against bacteria, yeast and mold. Of particular note are the activities against a wide range of mold. This polymeric solid does not crystallize and is sparingly soluble in all solvents. The monomeric, cationic, water-soluble Ag(I)N bonding complex, [Ag(Himd)2](NO3) (2), has also shown wide spectra of effective antimicrobial activities. These activities observed here were significantly different from those of the recently prepared oligomeric (Ag(I)S bonding complexes; the latter have shown narrow spectra. It is proposed that the Ag(I)N bonding is one of the key factors showing the wide spectra of antimicrobial activities and the potential targets for inhibition of bacteria and yeast by these Ag(I) complexes are proteins, but not nucleic acids. The physico-chemical properties of (1), in comparison with those of (2), with various measurements (FT-IR, Laser Raman scattering spectroscopy, ESCA and solid 13C CP-MAS NMR spectroscopies) are described.Keywords
This publication has 20 references indexed in Scilit:
- The biological chemistry of gold: A Metallo-drug and heavy-atom label with variable valencyPublished by Springer Science and Business Media LLC ,2007
- Metal Compounds in Therapy and DiagnosisScience, 1993
- Effects of gold(I) antiarthritic drugs and related compounds on Pseudomonas putidaJournal of Inorganic Biochemistry, 1992
- Reactions of auranofin ((1-thio-.beta.-D-glucopyranose 2,3,4,6-tetraacetato-S)(triethylphosphine)gold(I)) in aqueous hydrochloric acidInorganic Chemistry, 1987
- Antiarthritic Gold Compounds Effectively Quench Electronically Excited Singlet OxygenScience, 1987
- Gold-197 Moessbauer studies of some gold(I) thiolates and their phosphine complexes including certain antiarthritic gold drugsInorganic Chemistry, 1983
- An EXAFS study of gold co-ordination in the anti-arthritic drugs Myocrisin and SolganolJournal of the Chemical Society, Chemical Communications, 1980
- The chemistry of the gold drugs used in the treatment of rheumatoid arthritisChemical Society Reviews, 1980
- Bis(l-cysteinato)gold(I): Chemical characterization and identification in renal cortical cytoplasmaJournal of Inorganic Biochemistry, 1979
- Oral gold. Antiarthritic properties of alkylphosphinegold coordination complexesJournal of Medicinal Chemistry, 1972