Lifetime physical activity and the risk of amyotrophic lateral sclerosis
- 16 February 2013
- journal article
- Published by BMJ in Journal of Neurology, Neurosurgery & Psychiatry
- Vol. 84 (9), 976-981
- https://doi.org/10.1136/jnnp-2012-304724
Abstract
It has been hypothesised that physical activity is a risk factor for developing amyotrophic lateral sclerosis (ALS), fuelled by observations that professional soccer players and Gulf War veterans are at increased risk. In a population based study, we determined the relation between physical activity and risk of sporadic ALS, using an objective approach for assessing physical activity. 636 sporadic ALS patients and 2166 controls, both population based, completed a semistructured questionnaire on lifetime history of occupations, sports and hobbies. To objectively compare the energy cost of a lifetime history of occupational and leisure time physical activities and to reduce recall bias, metabolic equivalent scores were assigned to each activity based on the Compendium of Physical Activities. ALS patients had significantly higher levels of leisure time physical activity compared with controls (OR 1.08, 95% CI 1.02 to 1.14, p=0.008). No significant difference was found between patients and controls in the level of vigorous physical activities, including marathons and triathlons, or in occupational activity. Cumulative measures of physical activity in quartiles did not show a dose-response relationship. An increased risk of ALS with higher levels of leisure time physical activity was found in the present study. The lack of association with occupational physical activity and the absence of a dose-response relationship strengthen the hypothesis that not increased physical activity per se but rather a genetic profile or lifestyle promoting physical fitness increases ALS susceptibilitThis publication has 38 references indexed in Scilit:
- Neurodegenerative causes of death among retired National Football League playersNeurology, 2012
- Family history of neurodegenerative and vascular diseases in ALSNeurology, 2011
- Amyotrophic lateral sclerosisThe Lancet, 2011
- Job strain, hypoxia and risk of amyotrophic lateral sclerosis: Results from a death certificate studyAmyotrophic Lateral Sclerosis, 2010
- ALS in Italian professional soccer players: The risk is still present and could be soccer-specificAmyotrophic Lateral Sclerosis, 2009
- Physical activity as an exogenous risk factor in motor neuron disease (MND): A review of the evidenceAmyotrophic Lateral Sclerosis, 2009
- Prospective study of military service and mortality from ALSNeurology, 2005
- Severely increased risk of amyotrophic lateral sclerosis among Italian professional football playersBrain, 2005
- An Evidence-Based Medicine Approach to the Evaluation of the Role of Exogenous Risk Factors in Sporadic Amyotrophic Lateral SclerosisNeuroepidemiology, 2003
- Hypotheses to explain the association between vigorous physical activity and amyotrophic lateral sclerosisMedical Hypotheses, 1991