Autophagy and cancer – insights from mouse models
- 3 October 2017
- journal article
- review article
- Published by Wiley in The FEBS Journal
- Vol. 285 (5), 792-808
- https://doi.org/10.1111/febs.14274
Abstract
(Macro-)autophagy is an evolutionary conserved ‘self-digestion program’ that serves to maintain cellular metabolism and is implicated in many pathological processes such as cancer. In recent years, an increasing number of studies in murine cancer models have provided a plethora of sometimes conflicting results about the role of autophagy in cancer biology. This review summarizes these studies and raises awareness that there are situations in which autophagy blockage might indeed reduce tumor growth, but that sometimes the exact opposite is the case. It is therefore vital to mimic patient conditions in preclinical mouse experiments as thoroughly as possible before commencing clinical trials.Keywords
Funding Information
- Deutsche Forschungsgemeinschaft (FOR2314)
This publication has 80 references indexed in Scilit:
- Termination of autophagy and reformation of lysosomes regulated by mTORNature, 2010
- Mammalian autophagy: core molecular machinery and signaling regulationCurrent Opinion in Cell Biology, 2010
- Autophagy and tumorigenesisFEBS Letters, 2009
- An Overview of the Molecular Mechanism of AutophagyPublished by Springer Science and Business Media LLC ,2009
- Inactivation of FIP200 Leads to Inflammatory Skin Disorder, but Not Tumorigenesis, in Conditional Knock-out Mouse ModelsOnline Journal of Public Health Informatics, 2009
- Autophagy fights disease through cellular self-digestionNature, 2008
- Autophagy in the Pathogenesis of DiseaseCell, 2008
- The role of autophagy in cancer development and response to therapyNature Reviews Cancer, 2005
- Impairment of starvation-induced and constitutive autophagy in Atg7-deficient miceThe Journal of cell biology, 2005
- The role of autophagy during the early neonatal starvation periodNature, 2004