A Sensitive Double-Isotope Derivative Assay for Norepinephrine and Epinephrine
- 1 January 1970
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in Circulation Research
- Vol. 26 (1), 53-57
- https://doi.org/10.1161/01.res.26.1.53
Abstract
A sensitive and specific double-isotope dilution method for assaying norepinephrine and epinephrine separately is described. The method is based on enzymatic conversion of these two catecholamines to their respective metanephrines and was applied successfully to measurement of resting plasma concentrations of norepinephrine and epinephrine in normal subjects with the finding that norepinephrine (0.20 ± 0.08 µg/liter) normally constitutes approximately 80% of the plasma catecholamine content and epinephrine (0.05 ± 0.03 µg/liter) 20%.Keywords
This publication has 5 references indexed in Scilit:
- A Sensitive and Specific Double-Isotope Derivative Method for the Determination of Catecholamines in Biological SpecimensThe American Journal of the Medical Sciences, 1968
- Metabolism of α-methyltyrosine in man: relationship to its potency as an inhibitor of catecholamine biosynthesisJCI Insight, 1968
- In‐Vivo Decarboxylation of α‐Methyl DOPA and α‐Methyl MetatyrosineActa Physiologica Scandinavica, 1962
- Catechol Amines in UrinePublished by Elsevier BV ,1961
- THE SIMULTANEOUS FLUORIMETRIC DETERMINATION OF ADRENALINE AND NORADRENALINE IN PLASMA—I*Journal of Neurochemistry, 1957