Invading one step at a time: the role of invadopodia in tumor metastasis
Open Access
- 30 September 2013
- journal article
- review article
- Published by Springer Science and Business Media LLC in Oncogene
- Vol. 33 (33), 4193-4202
- https://doi.org/10.1038/onc.2013.393
Abstract
The ability to degrade extracellular matrix is critical for tumor cells to invade and metastasize. Recent studies show that tumor cells use specialized actin-based membrane protrusions termed invadopodia to perform matrix degradation. Invadopodia provide an elegant way for tumor cells to precisely couple focal matrix degradation with directional movement. Here we discuss several key components and regulators of invadopodia that have been uniquely implicated in tumor invasion and metastasis. Furthermore, we discuss existing and new therapeutic opportunities to target invadopodia for anti-metastasis treatment.Keywords
This publication has 118 references indexed in Scilit:
- Inhibition of MT1-MMP activity using functional antibody fragments selected against its hemopexin domainThe International Journal of Biochemistry & Cell Biology, 2012
- Twist1-Induced Invadopodia Formation Promotes Tumor MetastasisCancer Cell, 2011
- Sensing and Modulation of Invadopodia across a Wide Range of RigiditiesBiophysical Journal, 2011
- Epithelial-Mesenchymal Transitions in Development and DiseaseCell, 2009
- Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin SignalingCell, 2009
- Latent Bone Metastasis in Breast Cancer Tied to Src-Dependent Survival SignalsCancer Cell, 2009
- Identification of invasion specific splice variants of the cytoskeletal protein Mena present in mammary tumor cells during invasion in vivoClinical & Experimental Metastasis, 2008
- Cortactin in tumor invasivenessCancer Letters, 2008
- MT1-MMP-Dependent Invasion Is Regulated by TI-VAMP/VAMP7Current Biology, 2008
- Effect of fibroblast activation protein and α2-antiplasmin cleaving enzyme on collagen Types I, III, and IVArchives of Biochemistry and Biophysics, 2007