Changes in peroxisome proliferator-activated receptor-gamma activity in children with septic shock
- 17 September 2009
- journal article
- research article
- Published by Springer Science and Business Media LLC in Intensive Care Medicine
- Vol. 36 (1), 123-130
- https://doi.org/10.1007/s00134-009-1654-6
Abstract
To assess changes in peroxisome proliferator-activated receptor-γ (PPARγ) in peripheral blood mononuclear cells (PBMC) from critically ill children with sepsis. Additionally, to investigate the effects of sepsis on the endogenous activator of PPARγ, 15-deoxy-∆12,14-PGJ2 (15d-PGJ2), and the downstream targets of PPARγ activity, adiponectin and resistin.This publication has 44 references indexed in Scilit:
- Adiponectin deficiency is associated with severe polymicrobial sepsis, high inflammatory cytokine levels, and high mortalitySurgery, 2009
- Glucocorticoid receptor mRNA levels are selectively decreased in neutrophils of children with sepsisIntensive Care Medicine, 2009
- Sepsis-induced inhibition of neutrophil chemotaxis is mediated by activation of peroxisome proliferator-activated receptor-γBlood, 2008
- Adiponectin deficiency promotes endothelial activation and profoundly exacerbates sepsis-related mortalityAmerican Journal of Physiology-Endocrinology and Metabolism, 2008
- Pronounced elevation of resistin correlates with severity of disease in severe sepsis and septic shockCritical Care Medicine, 2007
- Signal Transducer and Activator of Transcription 5b Promotes Mucosal Tolerance in Pediatric Crohn's Disease and Murine ColitisThe American Journal of Pathology, 2006
- 15-DEOXY-??12,14-PROSTAGLANDIN J2 (15D-PGJ2), A PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ?? LIGAND, REDUCES TISSUE LEUKOSEQUESTRATION AND MORTALITY IN ENDOTOXIC SHOCKShock, 2005
- HEPATIC PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR-γ (PPAR-γ) IS DOWNREGULATED IN SEPSIS.Shock, 2004
- Induction of Adipocyte Complement-Related Protein of 30 Kilodaltons by PPAR Agonists: A Potential Mechanism of Insulin SensitizationEndocrinology, 2002
- Adipose Tissue Resistin Expression Is Severely Suppressed in Obesity and Stimulated by Peroxisome Proliferator-activated Receptor γ AgonistsOnline Journal of Public Health Informatics, 2001