LDL receptor-related proteins 5 and 6 in Wnt/β-catenin signaling:Arrows point the way
Top Cited Papers
- 15 April 2004
- journal article
- review article
- Published by The Company of Biologists in Development
- Vol. 131 (8), 1663-1677
- https://doi.org/10.1242/dev.01117
Abstract
Wnt signaling through the canonical β-catenin pathway plays essential roles in development and disease. Low-density-lipoprotein receptor-related proteins 5 and 6 (Lrp5 and Lrp6) in vertebrates, and their Drosophila ortholog Arrow, are single-span transmembrane proteins that are indispensable for Wnt/β-catenin signaling, and are likely to act as Wnt co-receptors. This review highlights recent progress and unresolved issues in understanding the function and regulation of Arrow/Lrp5/Lrp6 in Wnt signaling. We discuss Arrow/Lrp5/Lrp6 interactions with Wnt and the Frizzled family of Wnt receptors, and with the intracellular β-catenin degradation apparatus. We also discuss the regulation of Lrp5/Lrp6 by other extracellular ligands, and LRP5 mutations associated with familial osteoporosis and other disorders.Keywords
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