Lack of the canonical pRB-binding domain in the E7 ORF of artiodactyl papillomaviruses is associated with the development of fibropapillomas
Open Access
- 1 May 2004
- journal article
- research article
- Published by Microbiology Society in Journal of General Virology
- Vol. 85 (5), 1243-1250
- https://doi.org/10.1099/vir.0.19765-0
Abstract
The L-X-C-X-E pRB-binding motif of papillomavirus (PV) E7 proteins has been implicated in the immortalization and transformation of the host cell. However, sequencing of the complete genomes of bovine papillomavirus type 3 (BPV-3), bovine papillomavirus type 5 (BPV-5), equine papillomavirus (EQPV) and reindeer (Rangifer tarandus) papillomavirus (RPV) supports the notion that the pRB-binding motif is not ubiquitous among E7 proteins in the PV proteome. Key among the animal groups that lack the pRB-binding domain are the artiodactyl PVs, including European elk PV (EEPV), deer PV (DPV), reindeer PV (RPV), ovine PVs types 1 and 2 (OvPV-1 and -2) and bovine PVs 1, 2 and 5 (BPV-1, -2 and -5). Whereas the presence of the pRB-binding domain is normally associated with papillomas, the artiodactyl PVs are marked by the development of fibropapillomas on infection. Previous studies emphasized the role of E5 in the pathogenic mechanism of fibropapilloma development, but correlation between the lack of an E7 pRB-binding domain and the unique pathology of the artiodactyl PVs suggests a more complicated mechanism and an early evolutionary divergence from a pRB-binding ancestor.Keywords
This publication has 32 references indexed in Scilit:
- Role of LXCXE motif-dependent interactions in the activity of the retinoblastoma proteinOncogene, 2001
- Cooperative Transformation and Coexpression of Bovine Papillomavirus Type 1 E5 and E7 ProteinsJournal of Virology, 2001
- Role of the LXCXE Binding Site in Rb FunctionMolecular and Cellular Biology, 2000
- Human papillomavirus E7 proteins stimulate proliferation independently of their ability to associate with retinoblastoma proteinOncogene, 2000
- Gapped BLAST and PSI-BLAST: a new generation of protein database search programsNucleic Acids Research, 1997
- Bovine Papillomavirus Type 5: Partial Sequence and Comparison with Other Bovine PapillomavirusesVirus Genes, 1997
- Bovine cutaneous papillomas associated with bovine papillomavirus type 5Archiv für die gesamte Virusforschung, 1994
- Primer-Directed Sequencing of Human Papillomavirus TypesPublished by Springer Science and Business Media LLC ,1994
- Molecular Cloning of Bovine Papillomavirus Genomes and Comparison of Their Sequence Homologies by Heteroduplex MappingJournal of General Virology, 1982
- Molecular heterogeneity and lesion site specificity of cutaneous bovine papillomavirusesVirology, 1981