Abnormalities of the electron transport chain in idiopathic parkinson's disease
- 1 December 1989
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 26 (6), 719-723
- https://doi.org/10.1002/ana.410260606
Abstract
Idiopathic Parkinson's disease may have a low-level familial association but does not follow mendelian patterns of inheritance. Since inheritance of some components of the electron transport chain is nonmendelian and since inhibition of the electron transport chain with the toxin 1-methy1-4-phenyl-1,2,3,6-tetrahydropyridine models Parkinson's disease in humans and animals, we evaluated catalytic activities of the electron transport chain in platelet mitochondria purified from patients with idiopathic Parkinson's disease. All 10 patients studied had significant reductions of complex I (NADH:ubiquinone oxidoreductase) activity. Succinate:cytochrome c oxidoreductase activity was less strikingly reduced. We hypothesize that the complex I abnormality may have an etiological role in the pathogenesis of Parkinson's disease and that this defect may be derived via the mitochondrial genome.This publication has 32 references indexed in Scilit:
- A Defect in Mitochondrial Electron-Transport Activity (NADH–Coenzyme Q Oxidoreductase) in Leber's Hereditary Optic NeuropathyThe New England Journal of Medicine, 1989
- Mitochondrial DNA Mutation Associated with Leber's Hereditary Optic NeuropathyScience, 1988
- Monozygotic twins with Parkinson's diseaseAnnals of Neurology, 1986
- Inhibition of mitochondrial NADH dehydrogenase by pyridine derivatives and its possible relation to experimental and idiopathic parkinsonismBiochemical and Biophysical Research Communications, 1986
- Uptake of the neurotoxin 1-methyl-4-phenylpyridine (MPP+) by mitochondria and its relation to the inhibition of the mitochondrial oxidation of NAD+-linked substrates by MPP+Biochemical and Biophysical Research Communications, 1986
- Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridineLife Sciences, 1985
- Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog SynthesisScience, 1983
- Maternal inheritance of human mitochondrial DNA.Proceedings of the National Academy of Sciences of the United States of America, 1980
- Maternal and cytoplasmic inheritance of mitochondrial DNA in XenopusDevelopmental Biology, 1972
- ParkinsonismNeurology, 1967