Reduction of inhibition in the inferior colliculus after inner hair cell loss
- 2 October 2006
- journal article
- research article
- Published by Ovid Technologies (Wolters Kluwer Health) in NeuroReport
- Vol. 17 (14), 1493-1497
- https://doi.org/10.1097/01.wnr.0000234754.11431.ee
Abstract
Effects of carboplatin-induced partial loss of inner hair cells on rate-level functions of neurons in the central nucleus of the inferior colliculus of the same chinchillas before and 1-3 months after carboplatin treatment were examined. Partial inner hair cell loss caused only a small elevation of response thresholds but induced a significant increase in the proportion of monotonic and a significant decrease in the proportion of non-monotonic rate-level functions at the characteristic frequency of 210 multiunits. This indicates that inhibition in the inferior colliculus is reduced after sensory deafferentation. We conclude that some of the functional changes reported in the auditory cortex after peripheral deafferentation are already realized at the level of the inferior colliculus.Keywords
This publication has 19 references indexed in Scilit:
- Functional reorganization in chinchilla inferior colliculus associated with chronic and acute cochlear damageHearing Research, 2002
- Plastic Changes in the Central Auditory System After Hearing Loss, Restoration of Function, and During LearningPhysiological Reviews, 2002
- Auditory plasticity and hyperactivity following cochlear damageHearing Research, 2000
- Inner hair cell loss leads to enhanced response amplitudes in auditory cortex of unanesthetized chinchillas: evidence for increased system gainHearing Research, 1999
- Interaction between auditory and somatosensory systems: a study of evoked potentials in the inferior colliculusElectroencephalography and Clinical Neurophysiology/Evoked Potentials Section, 1993
- The effects of GABAergic inhibition on monaural response properties of neurons in the mustache bat's inferior colliculusHearing Research, 1993
- Neuronal discharge rate is unsuitable for encoding sound intensity at the inferior-colliculus levelHearing Research, 1988
- Effect of noise on auditory evoked responses in awake guina pigsHearing Research, 1987
- Single-neuron labeling and chronic cochlear pathology. IV. Stereocilia damage and alterations in rate- and phase-level functionsHearing Research, 1984
- SOME DISCHARGE CHARACTERISTICS OF SINGLE NEURONS IN THE INFERIOR COLLICULUS OF THE CAT. II. TIMING OF THE DISCHARGES AND OBSERVATIONS ON BINAURAL STIMULATIONJournal of Neurophysiology, 1963