Novel concepts in virally induced asthma
Open Access
- 20 January 2009
- journal article
- Published by Springer Science and Business Media LLC in Clinical and Molecular Allergy
- Vol. 7 (1), 2
- https://doi.org/10.1186/1476-7961-7-2
Abstract
Viruses are the predominant infectious cause of asthma exacerbations in the developed world. In addition, recent evidence strongly suggests that viral infections may also have a causal role in the development of childhood asthma. In this article, we will briefly describe the general perception of how the link between infections and asthma has changed over the last century, and then focus on very recent developments that have provided new insights into the contribution of viruses to asthma pathogenesis. Highlighted areas include the contribution of severe early life viral infections to asthma inception, genetic determinants of severe viral infections in infancy, the differences in innate and adaptive immune system cytokine responses to viral infection between asthmatic and nonasthmatic subjects, and a potential vaccine strategy to prevent severe early life virally-induced illness.Keywords
This publication has 37 references indexed in Scilit:
- Evidence of a Causal Role of Winter Virus Infection during Infancy in Early Childhood AsthmaAmerican Journal of Respiratory and Critical Care Medicine, 2008
- Cytokine response after severe respiratory syncytial virus bronchiolitis in early lifeJournal of Allergy and Clinical Immunology, 2008
- Wheezing Rhinovirus Illnesses in Early Life Predict Asthma Development in High-Risk ChildrenAmerican Journal of Respiratory and Critical Care Medicine, 2008
- Rhinovirus-induced lower respiratory illness is increased in asthma and related to virus load and Th1/2 cytokine and IL-10 productionProceedings of the National Academy of Sciences of the United States of America, 2008
- Genetic Susceptibility to Respiratory Syncytial Virus Bronchiolitis Is Predominantly Associated with Innate Immune GenesThe Journal of Infectious Diseases, 2007
- The absence of enhanced disease with wild type respiratory syncytial virus infection occurring after receipt of live, attenuated, respiratory syncytial virus vaccinesVaccine, 2007
- Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirusThe Journal of Experimental Medicine, 2005
- The association of viral and bacterial respiratory infections with exacerbations of wheezing in young asthmatic childrenThe Journal of Pediatrics, 1973
- Studies in bacterial allergyJournal of Allergy, 1949
- Vaccine therapy: The uses and misuses: A statistical bacteriologic studyJournal of Allergy, 1933