Retention rates and identification of factors associated with anti-TNFα, anti-IL17, and anti-IL12/23R agents discontinuation in psoriatic arthritis patients: results from a real-world clinical setting
- 1 September 2020
- journal article
- research article
- Published by Springer Science and Business Media LLC in Clinical Rheumatology
- Vol. 39 (9), 2663-2670
- https://doi.org/10.1007/s10067-020-05027-1
Abstract
Introduction Biologic disease-modifying antirheumatic drugs (bDMARDs) play a pivotal role in the treatment of psoriatic arthritis (PsA). Despite this, their discontinuation due to inefficacy or adverse events is often observed. The aims of this study are to describe retention rates and treatment trends of anti-TNF alpha, anti-IL17, and anti-IL12/23R agents in patients with PsA and to identify factors associated with bDMARDs discontinuation in a real-world clinical setting. Methods A retrospective cohort study based on the analysis of the three Italian prescription cohorts of patients with PsA has been performed. Survival analysis was performed using Kaplan-Meier curves and Cox proportional-hazards model. Results During the follow up, which lasted 25.5 (12-60) months, 68 patients discontinued a bDMARD: 13 for primary failure, 12 for secondary failure, 15 for adverse events, 5 for remission, 12 because of lost at follow-up, and 11 for other causes. Cox proportional-hazards demonstrated that a shorter disease duration (HR 0.994991, 95% CI 0.9910336-0.9989647, p = 0.014) and first-line bDMARD (HR 0.5090986, 95% CI 0.3073519-0.8432722, p = 0.009) have a protective role on bDMARD retention rate, while the multivariable analysis failed in demonstrating an independent protective role of male sex on drug retention rate (p = 0.083). No significant differences in retention rate have been found regarding biologic drugs, combination therapy or monotherapy, and class of bDMARD (anti-TNF alpha or anti-pIL12/23R and anti-IL-17). Conclusions This study shows that a shorter disease duration and treatment with a first-line bDMARD are predictors of bDMARDs retention rate, further highlighting the importance of early diagnosis of PsA.This publication has 28 references indexed in Scilit:
- Psoriatic disease treatment nowadays: unmet needs among the "jungle of biologic drugs and small molecules"Clinical Rheumatology, 2018
- Small molecule therapy for managing moderate to severe psoriatic arthritisExpert Opinion on Pharmacotherapy, 2017
- Psoriatic arthritis and psoriasis: differential diagnosisClinical Rheumatology, 2016
- Emerging drugs for psoriatic arthritisEmerging Drugs, 2016
- Progress in understanding and utilizing TNF-α inhibition for the treatment of psoriatic arthritisExpert Review of Clinical Immunology, 2015
- Role of Agents other than Tumor Necrosis Factor Blockers in the Treatment of Psoriatic ArthritisThe Journal of Rheumatology, 2015
- Pharmacological treatment of spondyloarthritis: exploring the effectiveness of nonsteroidal anti-inflammatory drugs, traditional disease-modifying antirheumatic drugs and biological therapiesTherapeutic Advances in Chronic Disease, 2015
- Simple clinical indicators for early psoriatic arthritis detectionSpringerPlus, 2014
- Psoriatic arthritis and TNF inhibitors: advances on effectiveness and toxicityExpert Opinion on Biological Therapy, 2014
- Psoriatic arthritis: advances in pharmacotherapy based on molecular targetExpert Opinion on Pharmacotherapy, 2013