N-Terminal Pro-Brain Natriuretic Peptide After Myocardial Infarction
- 1 January 2002
- journal article
- Published by Ovid Technologies (Wolters Kluwer Health) in Hypertension
- Vol. 39 (1), 99-104
- https://doi.org/10.1161/hy0102.100537
Abstract
N-terminal pro-brain natriuretic peptide (NT-proBNP) is increased early after acute myocardial infarction. We assessed the relationship of NT-proBNP with left ventricular function and mass as well as with renal function, hemodynamic, and anthropometric variables in 625 outpatients in the chronic phase after myocardial infarction and 465 siblings without infarction (control). NT-proBNP was measured by nonextracted, enzyme-linked, sandwich immunoassay. NT-proBNP was correlated with left ventricular ejection fraction, mass index, and renal function, in addition to infarction history, gender, and age, in univariate and multivariate analysis (all P P P <0.01). Patients with an ejection fraction <35% were detected by NT-proBNP with a sensitivity, specificity, and negative predictive value of 75%, 62%, and 99%, respectively, at an optimal cutoff of 44 pmol/L. Patients with an ejection fraction <35% and concomitant left ventricular hypertrophy were detected with a sensitivity, specificity, and negative predictive value of 90%, 80%, and 99.9%, respectively, at a cutoff of 76 pmol/L. Similar results were obtained for patients with an ejection fraction <35% and concomitant renal dysfunction at a cutoff of 162 pmol/L. NT-proBNP is a biochemical marker of integrated cardio-renal function in the chronic phase after myocardial infarction and a potential diagnostic tool for the detection and exclusion of significant left ventricular dysfunction. Cutoff concentrations have to be chosen according to renal function to optimize the predictive value of NT-proBNP.Keywords
This publication has 16 references indexed in Scilit:
- Profile of plasma N-terminal proBNP following acute myocardial infarction. Correlation with left ventricular systolic dysfunctionPublished by Oxford University Press (OUP) ,2000
- Development of a novel, N-Terminal-proBNP (NT-proBNP) assay with a low detection limitScandinavian Journal of Clinical and Laboratory Investigation, 1999
- Biochemical detection of left-ventricular systolic dysfunctionThe Lancet, 1998
- Immunoreactive amino‐terminal pro‐brain natriuretic peptide (NT‐PROBNP): a new marker of cardiac impairmentClinical Endocrinology, 1997
- The Role of the Circulation in Processing pro-Brain Natriuretic Peptide (proBNP) to Amino-Terminal BNP and BNP-32Peptides, 1997
- Rapid transcriptional activation and early mRNA turnover of brain natriuretic peptide in cardiocyte hypertrophy. Evidence for brain natriuretic peptide as an "emergency" cardiac hormone against ventricular overload.JCI Insight, 1995
- Comparison of secretion pattern between A-type and B-type natriuretic peptides in patients with old myocardial infarctionJournal of the American College of Cardiology, 1995
- Brain natriuretic peptide as a marker for hypertensive left ventricular hypertrophy: Changes during 1-year antihypertensive therapy with angiotensin-converting enzyme inhibitorAmerican Journal Of Medicine, 1995
- ECAT angina pectoris study: baseline associations of haemostatic factors with extent of coronary arteriosclerosis and other coronary risk factors in 3000 patients with angina pectoris undergoing coronary angiographyEuropean Heart Journal, 1993
- Prediction of Creatinine Clearance from Serum CreatinineNephron, 1976