Stem cell technology for neurodegenerative diseases
- 20 May 2011
- journal article
- review article
- Published by Wiley in Annals of Neurology
- Vol. 70 (3), 353-361
- https://doi.org/10.1002/ana.22487
Abstract
Over the past 20 years, stem cell technologies have become an increasingly attractive option to investigate and treat neurodegenerative diseases. In the current review, we discuss the process of extending basic stem cell research into translational therapies for patients suffering from neurodegenerative diseases. We begin with a discussion of the burden of these diseases on society, emphasizing the need for increased attention toward advancing stem cell therapies. We then explain the various types of stem cells utilized in neurodegenerative disease research, and outline important issues to consider in the transition of stem cell therapy from bench to bedside. Finally, we detail the current progress regarding the applications of stem cell therapies to specific neurodegenerative diseases, focusing on Parkinson disease, Huntington disease, Alzheimer disease, amyotrophic lateral sclerosis, and spinal muscular atrophy. With a greater understanding of the capacity of stem cell technologies, there is growing public hope that stem cell therapies will continue to progress into realistic and efficacious treatments for neurodegenerative diseases. Ann Neurol 2011;70: 353–361.Keywords
This publication has 80 references indexed in Scilit:
- Somatic coding mutations in human induced pluripotent stem cellsNature, 2011
- Embryonic stem cell–specific microRNAs promote induced pluripotencyNature Biotechnology, 2009
- Effective GDNF brain delivery using microspheres—A promising strategy for Parkinson's diseaseJournal of Controlled Release, 2009
- Human neural stem cell grafts in the spinal cord of SOD1 transgenic rats: Differentiation and structural integration into the segmental motor circuitryJournal of Comparative Neurology, 2009
- Combined Immunosuppressive Agents or CD4 Antibodies Prolong Survival of Human Neural Stem Cell Grafts and Improve Disease Outcomes in Amyotrophic Lateral Sclerosis Transgenic MiceThe International Journal of Cell Cloning, 2006
- Amyotrophic lateral sclerosis: a consensus viewpoint on designing and implementing a clinical trialAmyotrophic Lateral Sclerosis, 2004
- Intravenous Administration of Human Umbilical Cord Blood Cells in a Mouse Model of Amyotrophic Lateral Sclerosis: Distribution, Migration, and DifferentiationJournal of Hematotherapy & Stem Cell Research, 2003
- Dementia epidemiologyMedical Clinics of North America, 2002
- Differences in duration of Huntington's disease based on age at onsetJournal of Neurology, Neurosurgery & Psychiatry, 1999
- Single factors direct the differentiation of stem cells from the fetal and adult central nervous system.Genes & Development, 1996