The Relation between Estrogen Receptors and Response Rate to Cytotoxic Chemotherapy in Metastatic Breast Cancer
- 1 June 1978
- journal article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 298 (22), 1223-1228
- https://doi.org/10.1056/nejm197806012982203
Abstract
In a retrospective study we determined the relation between estrogen receptors and the response rate to cytotoxic chemotherapy in 70 patients with metastatic breast cancer. Thirty-four of 45 patients with low or absent estrogen-receptor values (10 fmol per milligram of cytoplasmic protein) responded (P<0.0001). There were no statistically significant differences between the two groups in age, menopausal status, disease-free interval, Karnofsky index or prior therapy. Differences in sites of involvement or type of chemotherapy did not account for the increased response rate in receptor-negative patients. We conclude that estrogen-receptor values are an important predictor of response to cytotoxic chemotherapy in metastatic breast cancer. (N Engl J Med 298:1223–1228, 1978)Keywords
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