Class II-Independent Generation of CD4 Memory T Cells from Effectors
- 12 November 1999
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 286 (5443), 1381-1383
- https://doi.org/10.1126/science.286.5443.1381
Abstract
The factors required for the generation of memory CD4 T cells remain unclear, and whether there is a continuing requirement for antigen stimulation is critical to design of vaccine strategies. CD4 effectors generated in vitro from naı̈ve CD4 T cells of mice efficiently gave rise to small resting memory cells after transfer to class II–deficient hosts, indicating no requirement for further antigen or class II recognition.Keywords
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