Bioactive Conformation of Luteinizing Hormone-Releasing Hormone: Evidence from a Conformationally Constrained Analog
- 7 November 1980
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 210 (4470), 656-658
- https://doi.org/10.1126/science.7001627
Abstract
An analog of luteinizing hormone-releasing hormone containing a gamma-lactam as a conformational constraint has been prepared with the use of a novel cyclization of a methionine sulfonium salt. The analog is more active as a luteinizing hormone-releasing hormone agonist that the parent hormone, and provides evidence for a bioactive conformation containing a beta-turn.Keywords
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