Inhibition of Hepatitis B Virus Replication by Interferon Requires Proteasome Activity†
Open Access
- 1 April 2002
- journal article
- Published by American Society for Microbiology in Journal of Virology
- Vol. 76 (7), 3570-3574
- https://doi.org/10.1128/jvi.76.7.3570-3574.2002
Abstract
Hepatitis B virus (HBV) replication is inhibited in a noncytopathic manner by alpha/beta interferon (IFN-α/β) and IFN-γ. We demonstrate here that inhibitors of cellular proteasome activity can block this antiviral effect. These results suggest that a critical component of the IFN-induced antiviral response may be the proteasome-dependent degradation of viral or cellular proteins that are required for HBV replication.This publication has 46 references indexed in Scilit:
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