Susceptibility of Pleuropneumonia-Like Organisms to Action of Antibiotics: II. Terramycin and Neomycin

Abstract

Terramycin HC1 inhibited growth of 8 human strains of pleuropneumonia-like organisms in the concns. of 0.5 [mu]g./ml. of medium, while neomycin HC1 was required in concns. of from 2.0 to 6.25 U./ml. of medium. Three patients infected with pleuropneumonia-like organisms, 2 of whom had Reiter''s syndrome, became asymptomatic and were free of the organisms after streptomycin therapy. Terramycin likewise brought about rapid disappearance of the organisms and clinical remission of symptoms in 7 cases of genito-urinary infections caused by pleuropneumonia-like organisms. Terramycin appears to be the antibiotic of choice for the treatment of infections with the pleuropneumonia like organisms.