NAD+/sirtuin metabolism is enhanced in response to cold‐induced changes in lipid metabolism in mouse liver
Open Access
- 30 March 2020
- journal article
- research article
- Published by Wiley in FEBS Letters
- Vol. 594 (11), 1711-1725
- https://doi.org/10.1002/1873-3468.13779
Abstract
The nicotinamide adenine dinucleotide (NAD+)/Sirtuin (SIRT) system is linked to metabolic adaptation. This study aimed to determine the temporal profile of metabolic responses of the liver to cold exposure and changes of the hepatic NAD+/SIRT system. Eight‐week‐old male C57BL/6 mice were individually housed in conventional cages under cold exposure (4°C) for up to five days. Cold exposure decreased the hepatic triglyceride level and cholesterol level in mice by 1.7‐ and 1.6‐fold, respectively. Lipogenic gene expression was persistently reduced, while gluconeogenic gene expression was transiently increased. Hepatic NAD+/SIRT metabolism was induced during the "cold remodeling" phase (days 1‐3) and correlated with decreasing lipogenic and increasing gluconeogenic gene expression, contributing to the maintenance of whole‐body lipid and glucose homeostasis.Keywords
Funding Information
- China Postdoctoral Science Foundation (2017M623196)
- National Natural Science Foundation of China (81700773, 81871190)
- Natural Science Foundation of Shaanxi Province (2019JQ‐217)
This publication has 48 references indexed in Scilit:
- Multiple effects of cold exposure on livers of male miceJournal of Endocrinology, 2018
- Cold-induced conversion of cholesterol to bile acids in mice shapes the gut microbiome and promotes adaptive thermogenesisNature Medicine, 2017
- Targeting NAD+ in Metabolic Disease: New Insights Into an Old MoleculeJournal of the Endocrine Society, 2017
- Thermogenic adipocytes promote HDL turnover and reverse cholesterol transportNature Communications, 2017
- Characterization of cold‐induced remodelling reveals depot‐specific differences across and within brown and white adipose tissues in miceActa Physiologica, 2016
- Brown adipose tissue takes up plasma triglycerides mostly after lipolysisJournal of Lipid Research, 2015
- Adipose tissue browning and metabolic healthNature Reviews Endocrinology, 2013
- The interaction of hepatic lipid and glucose metabolism in liver diseasesJournal of Hepatology, 2012
- Brown adipose tissue activity controls triglyceride clearanceNature Medicine, 2011
- Pharmacological Stimulation of NADH Oxidation Ameliorates Obesity and Related Phenotypes in MiceDiabetes, 2009