The cellular niche of Listeria monocytogenes infection changes rapidly in the spleen
Open Access
- 29 January 2009
- journal article
- research article
- Published by Wiley in European Journal of Immunology
- Vol. 39 (2), 417-425
- https://doi.org/10.1002/eji.200838718
Abstract
The spleen is an important organ for the host response to systemic bacterial infections. Many cell types and cell surface receptors have been shown to play role in the capture and control of bacteria, yet these are often studied individually and a coherent picture has yet to emerge of how various phagocytes collaborate to control bacterial infection. We analyzed the cellular distribution of Listeria monocytogenes (LM) in situ during the early phase of infection. Using an immunohistochemistry approach, five distinct phagocyte populations contained LM after i.v. challenge and accounted for roughly all bacterial signal in tissue sections. Our analysis showed that LM was initially captured by a wide range of phagocytes in the marginal zone, where the growth of LM appeared to be controlled. The cellular distribution of LM within phagocyte populations changed rapidly during the first few hours, decreasing in marginal zone macrophages and transiently increasing in CD11c+ DC. After 4–6 h LM was transported to the periarteriolar lymphoid sheath where the infective foci developed and LM grew exponentially.Keywords
This publication has 46 references indexed in Scilit:
- Geography and plumbing control the T cell response to infectionImmunology & Cell Biology, 2008
- Differential Antigen Processing by Dendritic Cell Subsets in VivoScience, 2007
- Essential Role of CCL2 in Clustering of Splenic ERTR-9 + Macrophages during Infection of BALB/c Mice by Listeria monocytogenesInfection and Immunity, 2007
- Differential expansion, activation and effector functions of conventional and plasmacytoid dendritic cells in mouse tissues transiently infected with Listeria monocytogenesCellular Microbiology, 2006
- Neutrophils and immunity: challenges and opportunitiesNature Reviews Immunology, 2006
- Structure and function of the spleenNature Reviews Immunology, 2005
- Immune responses to Listeria monocytogenesNature Reviews Immunology, 2004
- Characterization of Recombinant Soluble Macrophage Scavenger Receptor MARCOPublished by Elsevier BV ,2002
- The anatomy of peripheral lymphoid organs with emphasis on accessory cells: Light‐microscopic immunocytochemical studies of mouse spleen, lymph node, and peyer's patchJournal of Anatomy, 1984
- F4/80, a monoclonal antibody directed specifically against the mouse macrophageEuropean Journal of Immunology, 1981