The human parasite Loa loa in cytokine and cytokine receptor gene knock out BALB/c mice: survival, development and localization
Open Access
- 21 February 2012
- journal article
- research article
- Published by Springer Science and Business Media LLC in Parasites & Vectors
- Vol. 5 (1), 43-8
- https://doi.org/10.1186/1756-3305-5-43
Abstract
Immunological mechanisms involved in the survival and development of human filarial species in the vertebrate host are poorly known due to the lack of suitable experimental models. In order to understand the role of cytokines in the survival and development of filarial larvae in the vertebrate host, we infected different strains of BALB/c mice deficient in a number of cytokine or cytokine receptor genes with Loa loa. The survival and development of larvae were monitored.Keywords
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