The adaptation of the blood‐brain barrier to vascular endothelial growth factor and placental growth factor during pregnancy
Open Access
- 12 September 2011
- journal article
- research article
- Published by Wiley in The FASEB Journal
- Vol. 26 (1), 355-362
- https://doi.org/10.1096/fj.11-191916
Abstract
Vascular endothelial growth factor (VEGF) and placental growth factor (PLGF) are increased in the maternal circulation during pregnancy. These factors may increase blood-brain barrier (BBB) permeability, yet brain edema does not normally occur during pregnancy. We therefore hypothesized that in pregnancy, the BBB adapts to high levels of these permeability factors. We investigated the influence of pregnancy-related circulating factors on VEGF-induced BBB permeability by perfusing cerebral veins with plasma from nonpregnant (NP) or late-pregnant (LP) rats (n=6/group) and measuring permeability in response to VEGF. The effect of VEGF, PLGF, and VEGF-receptor (VEGFR) activation on BBB permeability was also determined. Results showed that VEGF significantly increased permeability (×107μm3/min) from 9.7 ± 3.5 to 21.0 ± 1.5 (P0.05). Both LP plasma and soluble FMS-like tyrosine-kinase 1 (sFlt1) in NP plasma abolished VEGF-induced BBB permeability in NP veins (9.5±2.9 and 12±2.6; P>0.05). PLGF significantly increased BBB permeability in NP plasma (18±1.4; PFASEB J. 26, 355–362 (2012). www.fasebj.orgKeywords
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