A new series of 560 patients with intracranial metastases, treated by irradiation, has been reviewed and the results are reported. In this series worthwhile palliation was obtained in 54 per cent of the total number of patients, and 80 per cent of the 376 patients who completed the planned course of irradiation, and were available for evaluation. The mean duration of remission was 5 months and the median duration 3 months. The use of supervoltage irradiation and adjuvant corticosteroids reduced radiation reactions and permitted easier administration of irradiation, but there was no influence on the over-all response rate or duration of response when compared to 250 kvp. irradiation without adjuvant corticosteroids. The results were comparable with those reported previously. Since most patients have multiple metastatic foci in brain, we continue to advocate total brain irradiation to a dose of 3,500 rads in 3 to 4 weeks.