Regulation and function of DNA methylation in plants and animals
Top Cited Papers
- 15 February 2011
- journal article
- review article
- Published by Springer Science and Business Media LLC in Cell Research
- Vol. 21 (3), 442-465
- https://doi.org/10.1038/cr.2011.23
Abstract
DNA methylation is an important epigenetic mark involved in diverse biological processes. In plants, DNA methylation can be established through the RNA-directed DNA methylation pathway, an RNA interference pathway for transcriptional gene silencing (TGS), which requires 24-nt small interfering RNAs. In mammals, de novo DNA methylation occurs primarily at two developmental stages: during early embryogenesis and during gametogenesis. While it is not clear whether establishment of DNA methylation patterns in mammals involves RNA interference in general, de novo DNA methylation and suppression of transposons in germ cells require 24-32-nt piwi-interacting small RNAs. DNA methylation status is dynamically regulated by DNA methylation and demethylation reactions. In plants, active DNA demethylation relies on the repressor of silencing 1 family of bifunctional DNA glycosylases, which remove the 5-methylcytosine base and then cleave the DNA backbone at the abasic site, initiating a base excision repair (BER) pathway. In animals, multiple mechanisms of active DNA demethylation have been proposed, including a deaminase- and DNA glycosylase-initiated BER pathway. New information concerning the effects of various histone modifications on the establishment and maintenance of DNA methylation has broadened our understanding of the regulation of DNA methylation. The function of DNA methylation in plants and animals is also discussed in this review. © 2011 IBCB, SIBS, CAS All rights reservedKeywords
This publication has 164 references indexed in Scilit:
- RNA-directed DNA methylation and demethylation in plantsScience China Life Sciences, 2009
- Epigenetic Reprogramming and Small RNA Silencing of Transposable Elements in PollenCell, 2009
- DNA Demethylation in Zebrafish Involves the Coupling of a Deaminase, a Glycosylase, and Gadd45Cell, 2008
- Noncoding Transcription by RNA Polymerase Pol IVb/Pol V Mediates Transcriptional Silencing of Overlapping and Adjacent GenesCell, 2008
- The Colorful History of Active DNA DemethylationCell, 2008
- Epigenome Sequencing Comes of AgeCell, 2008
- Highly Integrated Single-Base Resolution Maps of the Epigenome in ArabidopsisCell, 2008
- Genomic patterns of DNA methylation: targets and function of an epigenetic markCurrent Opinion in Cell Biology, 2007
- A Bivalent Chromatin Structure Marks Key Developmental Genes in Embryonic Stem CellsCell, 2006
- Targeted mutation of the DNA methyltransferase gene results in embryonic lethalityCell, 1992