Immunometabolism at the interface between macrophages and pathogens
- 24 January 2019
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Immunology
- Vol. 19 (5), 291-304
- https://doi.org/10.1038/s41577-019-0124-9
Abstract
It is generally regarded that the progression of an infection within host macrophages is the consequence of a failed immune response. However, recent appreciation of macrophage heterogeneity, with respect to both development and metabolism, indicates that the reality is more complex. Different lineages of tissue-resident macrophages respond divergently to microbial, environmental and immunological stimuli. The emerging picture that the developmental origin of macrophages determines their responses to immune stimulation and to infection stresses the importance of in vivo infection models. Recent investigations into the metabolism of infecting microorganisms and host macrophages indicate that their metabolic interface can be a major determinant of pathogen growth or containment. This Review focuses on the integration of data from existing studies, the identification of challenges in generating and interpreting data from ongoing studies and a discussion of the technologies and tools that are required to best address future questions in the field.Keywords
This publication has 158 references indexed in Scilit:
- 13C-Flux Spectral Analysis of Host-Pathogen Metabolism Reveals a Mixed Diet for Intracellular Mycobacterium tuberculosisCell Chemical Biology, 2013
- Zinc Sequestration by the Neutrophil Protein Calprotectin Enhances Salmonella Growth in the Inflamed GutCell Host & Microbe, 2012
- Mycobacterial P1-Type ATPases Mediate Resistance to Zinc Poisoning in Human MacrophagesCell Host & Microbe, 2011
- Toxoplasma Polymorphic Effectors Determine Macrophage Polarization and Intestinal InflammationCell Host & Microbe, 2011
- Listeria monocytogenes transiently alters mitochondrial dynamics during infectionProceedings of the National Academy of Sciences of the United States of America, 2011
- Copper resistance is essential for virulence of Mycobacterium tuberculosisProceedings of the National Academy of Sciences of the United States of America, 2011
- A replication clock for Mycobacterium tuberculosisNature Medicine, 2009
- Exploring the full spectrum of macrophage activationNature Reviews Immunology, 2008
- Mycobacterial persistence requires the utilization of host cholesterolProceedings of the National Academy of Sciences of the United States of America, 2008
- M. tuberculosis and M. leprae Translocate from the Phagolysosome to the Cytosol in Myeloid CellsCell, 2007