Duffy (Fy), DARC, and neutropenia among women from the United States, Europe and the Caribbean
Open Access
- 24 September 2008
- journal article
- Published by Wiley in British Journal of Haematology
- Vol. 143 (2), 288-293
- https://doi.org/10.1111/j.1365-2141.2008.07335.x
Abstract
Neutropenia associated with race/ethnicity has essentially been unexplained and, although thought to be benign, may affect therapy for cancer or other illnesses. A recent study linked a single nucleotide polymorphism (SNP) (rs2814778) in the Duffy antigen/receptor chemokine gene (DARC) with white blood cell count. We therefore analysed the association of the rs2814778 CC, TC and TT genotypes with absolute neutrophil count (ANC) among asymptomatic women from the Caribbean, Europe and the United States. Among 261 study participants, 33/47 women from Barbados/Trinidad-Tobago, 34/49 from Haiti, 26/37 from Jamaica, and 29/38 US-born black women, but only 4/50 from the Dominican Republic and 0/40 US- or European-born whites (P = 0·0001) had the CC genotype. In a linear regression model that included percentage African ancestry, national origin, cytokines, socio-economic factors and the ELA2 rs57834246 SNP, only the DARC rs2814778 genotype and C-reactive protein were associated with ANC (P < 0·0001). Women with the CC genotype had lower ANC than other women. Further research is needed on the associations of rs2814778 genotype with neutropenia and treatment delay in the setting of cancer. A better understanding of these associations may help to improve cancer outcomes among individuals of African ancestry.Keywords
This publication has 25 references indexed in Scilit:
- Neutropenia in 6 ethnic groups from the Caribbean and the U.S.Cancer, 2008
- Admixture Mapping of White Cell Count: Genetic Locus Responsible for Lower White Blood Cell Count in the Health ABC and Jackson Heart StudiesAmerican Journal of Human Genetics, 2008
- Genetic admixture, adipocytokines, and adiposity in Black Americans: the Health, Aging, and Body Composition studyHuman Genetics, 2007
- Entrez Gene: gene-centered information at NCBINucleic Acids Research, 2006
- Neutrophil elastase in cyclic and severe congenital neutropeniaBlood, 2006
- Enhanced expression of Duffy antigen receptor for chemokines by breast cancer cells attenuates growth and metastasis potentialOncogene, 2006
- Estimation of individual admixture: Analytical and study design considerationsGenetic Epidemiology, 2005
- Exercise induced mobilisation of the marginated granulocyte pool in the investigation of ethnic neutropeniaJournal of Clinical Pathology, 2000
- Ethnic and sex differences in the total and differential white cell count and platelet count.Journal of Clinical Pathology, 1996
- The Duffy antigen/receptor for chemokines (DARC) is expressed in endothelial cells of Duffy negative individuals who lack the erythrocyte receptor.The Journal of Experimental Medicine, 1995