Korean Addenbrooke's Cognitive Examination Revised (K‐ACER) for differential diagnosis of Alzheimer's disease and subcortical ischemic vascular dementia
- 17 May 2010
- journal article
- research article
- Published by Wiley in Geriatrics & Gerontology International
- Vol. 10 (4), 295-301
- https://doi.org/10.1111/j.1447-0594.2010.00624.x
Abstract
Aim: Sensitive, specific neuropsychological screening tests, such as the Addenbrooke's Cognitive Examination Revised (ACE‐R), are essential for dementia diagnosis. We aimed to validate the use of the Korean version of ACE‐R (K‐ACER) to differentiate Alzheimer's disease (AD) from subcortical ischemic vascular dementia (SIVD). Methods: Standard tests for dementia screening were applied to 156 subjects (84 controls, 30 AD, 42 SIVD), and total and sub‐domain scores on the K‐ACER, as well as the sub‐domain ratio (VLOM), were compared. Results: The reliability of the K‐ACER was very good (α‐coefficient 0.84), and cut‐off score for dementia was determined (cut‐off value 78, sensitivity 0.93, specificity 0.95). The likelihood ratio for dementia was calculated as between 78 and 82. At a cut‐off of 78, the likelihood of dementia was 18.6:1. Although a comparison of K‐ACER scores between AD and SIVD patients revealed significant differences in verbal fluency, language domain and VLOM ratio, sensitivity and specificity for differential diagnosis between AD and SVID proved less accurate. Conclusion: The K‐ACER is a rapid, sensitive and specific dementia screening test. Though sub‐domains of items may be useful for differentiating between AD and SIVD, sensitivity and specificity is less accurate than dementia screening itself. Geriatr Gerontol Int 2010; 10: 295–301.Keywords
This publication has 14 references indexed in Scilit:
- The Addenbrooke's Cognitive Examination Revised (ACE‐R): a brief cognitive test battery for dementia screeningInternational Journal of Geriatric Psychiatry, 2006
- Validation of the Spanish version of the Addenbrooke's Cognitive Examination in a rural community in SpainInternational Journal of Geriatric Psychiatry, 2006
- The French Addenbrooke’s Cognitive Examination Is Effective in Detecting Dementia in a French-Speaking PopulationDementia and Geriatric Cognitive Disorders, 2004
- Adaptation of the ACE for a Malayalam speaking population in southern IndiaInternational Journal of Geriatric Psychiatry, 2004
- Vascular dementia: still a debatable entity?Journal of the Neurological Sciences, 1996
- The Efficacy and Safety of Donepezil in Patients with Alzheimer's Disease: Results of a US Multicentre, Randomized, Double-Blind, Placebo-Controlled TrialDementia and Geriatric Cognitive Disorders, 1996
- Vascular pathology in three cases of progressive cognitive deteriorationJournal of the Neurological Sciences, 1996
- Stroke PreventionArchives of Neurology, 1995
- Clinical diagnosis of Alzheimer's diseaseNeurology, 1984
- A New Clinical Scale for the Staging of DementiaThe British Journal of Psychiatry, 1982