β‐Casomorphin‐7 Cause Decreasing in Oxidative Stress and Inhibiting NF‐κB‐iNOS‐NO Signal Pathway in Pancreas of Diabetes Rats
- 17 February 2012
- journal article
- Published by Wiley in Journal of Food Science
- Vol. 77 (2), C278-C282
- https://doi.org/10.1111/j.1750-3841.2011.02577.x
Abstract
β-Casomorphin-7 (β-CM-7) is a milk biological active peptide. The present study is aimed to investigate the protective effects of β-CM-7, against oxidative stress in pancreas of streptozotocin-induced diabetic rats by assaying malondialdehyde (MDA), nitric oxide (NO) level, the activity of enzymatic antioxidants such as superoxide dismutase (SOD), catalase, glutathione peroxidase (GSH-Px), and NF-κB, inducible nitric oxide synthase (iNOS) gene expression. A significant increase in the level of oxidative stress was observed in pancreas of the diabetic rats when compared to control rats. After 15 d oral administration of β-CM-7 (7.5 × 10−8mol/d), the pancreas MDA level was markedly reduced. Oral administration of β-CM-7 to diabetic rats showed an obviously increase in the activity of catalase in pancreas, oral administration of β-CM-7 to the diabetic group of rats also showed a reduction of NF-κB and iNOS gene expression in pancreas. The elevated pancreas NO level was markedly reduced by the oral administration of β-CM-7. Thus, the results of the present study suggest that β-CM-7 may cause protective effects such as pronounced decreasing in oxidative stress and inhibiting NF-κB-iNOS-NO signal pathway in pancreas of diabetes rats.Keywords
This publication has 28 references indexed in Scilit:
- Lutein protects HT-29 cells against Deoxynivalenol-induced oxidative stress and apoptosis: Prevention of NF-κB nuclear localization and down regulation of NF-κB and Cyclo-Oxygenase – 2 expressionFree Radical Biology & Medicine, 2010
- The antidiabetic effects of cysteinyl metformin, a newly synthesized agent, in alloxan- and streptozocin-induced diabetic ratsChemico-Biological Interactions, 2008
- Antihyperglycemic effect of a new thiazolidinedione analogue and its role in ameliorating oxidative stress in alloxan-induced diabetic ratsLife Sciences, 2007
- BENEFICIAL EFFECTS OF ALOE VERA LEAF GEL EXTRACT ON LIPID PROFILE STATUS IN RATS WITH STREPTOZOTOCIN DIABETESClinical and Experimental Pharmacology and Physiology, 2006
- Lipid Peroxidation in Diabetes MellitusAntioxidants and Redox Signaling, 2005
- Apoptosis and Mitochondrial Damage in INS-1 Cells Treated with Alloxan.Biological & Pharmaceutical Bulletin, 2001
- Preservation of the antioxidant status in chemically-induced diabetes mellitus by melatoninJournal of Pineal Research, 2000
- Enzymatic release of neocasomorphin and β-casomorphin from bovine β-caseinPeptides, 1999
- Bioactive peptides derived from milk proteins. Structural, physiological and analytical aspectsMolecular Nutrition & Food Research, 1995
- Novel Opioid Peptides Derived from Casein (β-Casomorphins). I. Isolation from Bovine Casein PeptoneHoppe-Seyler´s Zeitschrift für physiologische Chemie, 1979